James Abbruzzese Selected Research

Dinoprostone (PGE2)

11/2004

Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis.

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James Abbruzzese Research Topics

Disease

17	Neoplasms (Cancer) 01/2021 - 01/2001
12	Pancreatic Neoplasms (Pancreatic Cancer) 01/2018 - 11/2004
5	Adenocarcinoma 01/2021 - 01/2001
3	Colorectal Neoplasms (Colorectal Cancer) 01/2008 - 11/2002
2	Inflammation (Inflammations) 01/2018 - 09/2010
2	Neoplasm Metastasis (Metastasis) 12/2012 - 12/2007
1	Brain Neoplasms (Brain Tumor) 01/2021
1	Lung Neoplasms (Lung Cancer) 12/2009
1	Pain (Aches) 12/2009
1	Wound Infection (Wound Infections) 02/2009
1	Anorexia 02/2009
1	Proteinuria 02/2009
1	Gastrointestinal Hemorrhage (Hematochezia) 02/2009
1	Diarrhea 02/2009
1	Hyperbilirubinemia 02/2009
1	Hyperkalemia 02/2009
1	Thrombocytopenia (Thrombopenia) 02/2009
1	Back Pain (Backache) 02/2009
1	Hypertension (High Blood Pressure) 02/2009
1	Fatigue 02/2009
1	Hepatocellular Carcinoma (Hepatoma) 02/2009
1	Colonic Neoplasms (Colon Cancer) 01/2008
1	Squamous Cell Neoplasms (Squamous Cell Cancer) 04/2004
1	Carcinoma (Carcinomatosis) 11/2002
1	Viremia 11/2002

Drug/Important Bio-Agent (IBA)

5	Gemcitabine FDA Link 03/2011 - 09/2003
5	NF-kappa B (NF-kB)IBA 12/2009 - 11/2004
4	CurcuminIBA 01/2018 - 11/2004
3	Pharmaceutical PreparationsIBA 01/2018 - 02/2009
2	Platelet-Derived Growth FactorIBA 01/2018 - 12/2007
2	Biological ProductsIBA 04/2016 - 11/2004
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2010 - 12/2007
2	InterleukinsIBA 09/2010 - 12/2009
2	Interleukin-8 (Interleukin 8)IBA 12/2009 - 11/2004
2	CytokinesIBA 12/2009 - 11/2002
2	Erlotinib Hydrochloride (CP 358,774)FDA Link 02/2009 - 11/2006
2	GenisteinIBA 11/2006 - 10/2005
1	Lapatinib (GW572016)FDA Link 01/2021
1	Trastuzumab (Herceptin)FDA Link 01/2021
1	Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)IBA 01/2018
1	Messenger RNA (mRNA)IBA 01/2018
1	Sp Transcription FactorsIBA 01/2018
1	Metformin (Glucophage)FDA LinkGeneric 01/2018
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2018
1	Proteins (Proteins, Gene)FDA Link 01/2018
1	MicellesIBA 06/2015
1	cyclopamineIBA 06/2015
1	Neoplasm Antigens (Tumor Antigens)IBA 04/2011
1	VaccinesIBA 04/2011
1	SurvivinIBA 04/2011
1	ThioredoxinsIBA 03/2011
1	Renilla LuciferasesIBA 09/2010
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 09/2010
1	ChemokinesIBA 09/2010
1	Interferon-betaIBA 09/2010
1	bardoxolone methylIBA 09/2010
1	Analgesics (Analgesic Drugs)IBA 12/2009
1	DNA (Deoxyribonucleic Acid)IBA 12/2009
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2009
1	Interleukin-6 (Interleukin 6)IBA 12/2009
1	Interleukin-10 (Interleukin 10)IBA 12/2009
1	Interleukin-18 (Interleukin 18)IBA 12/2009
1	Transaminases (Aminotransferases)IBA 02/2009
1	Bevacizumab (Avastin)FDA Link 02/2009
1	Protein Glutamine gamma Glutamyltransferase 2IBA 04/2008
1	Focal Adhesion Protein-Tyrosine KinasesIBA 04/2008
1	PTEN Phosphohydrolase (PTEN Phosphatase)IBA 04/2008
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2008
1	Fluorouracil (Carac)FDA LinkGeneric 01/2008
1	Irinotecan (Camptosar)FDA LinkGeneric 01/2008
1	Small Interfering RNA (siRNA)IBA 12/2007
1	Complementary DNA (cDNA)IBA 12/2007
1	Matrix Metalloproteinases (MMPs)IBA 12/2007
1	ErbB Receptors (EGF Receptor)IBA 11/2006
1	Antineoplastic Agents (Antineoplastics)IBA 10/2005
1	IsoflavonesIBA 10/2005
1	I-kappa B KinaseIBA 11/2004
1	EnzymesIBA 11/2004
1	Transcription Factors (Transcription Factor)IBA 11/2004
1	Dinoprostone (PGE2)FDA Link 11/2004
1	PhytochemicalsIBA 11/2004
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 11/2004
1	Blood Proteins (Serum Proteins)IBA 01/2004
1	irofulvenIBA 04/2003
1	dl1520 (ONYX-015)IBA 11/2002
1	Neutralizing AntibodiesIBA 11/2002
1	Antiviral Agents (Antivirals)IBA 11/2002
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2001

Therapy/Procedure

8	Therapeutics 01/2021 - 01/2001
4	Drug Therapy (Chemotherapy) 01/2021 - 11/2002
2	Neoadjuvant Therapy 12/2012 - 01/2012
2	Aftercare (After-Treatment) 09/2010 - 11/2002
1	Immunotherapy 01/2021
1	Radiotherapy 06/2015
1	Pancreatectomy 12/2012
1	Pancreaticoduodenectomy 01/2012
1	Injections 09/2010
1	Analgesia 12/2009
1	Colostomy 04/2004
1	Combined Modality Therapy 04/2004